温州医科大学唐开福课题组2014年硕士研究生调剂信息

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一  研究生调剂信息：

1 今年拟招调剂研究生3名，主要从事肿瘤分子遗传学及表观遗传学研究

2 待遇：

（1）在校期间可以享受学校提供的各种助学金（相当于以往的公费录取）。

（2）除学校提供的生活补贴外，导师根据学生表现每月提供700-1000的劳务补贴。

（3）学校提供各类奖学金，最高可达2万元。

3 录取要求

（1）原则上总分数、单科须过国家分数线。

（2）对本实验室研究感兴趣，吃苦耐劳。

4  联系方式： tangkaifu@hotmail.com

二 唐开福课题组介绍

（1）本实验室师资力量雄厚

目前师生比例1:3。本课题组目前共有研究人员9名，包括3个老师（唐开福教授、吴建民副教授和李桂玲副教授）和6个研究生，吴建民副教授和李桂玲副教授协助唐开福教授指导研究生。
课题组3个老师都在国外从事相关研究多年：唐开福博士曾在德国和瑞士留学5年；李桂玲博士在美国和欧洲留学10年，吴建民博士曾在美国留学2年。

（2）课题组经费充足

唐开福目前承担项目见其简介；李桂玲博士目前承担“863”重大项目子课题1项、国家自然科学基金1项；吴建民博士承担国家自然科学基金等共3项。

（3）研究生培养质量优良

本课题组师生比例一直维持在1:3-1:4之间，按精英模式培养。已毕业研究生的质量得到了国内外高校认可，毕业生大多去了国内外一流大学及研究所（如清华大学、NIBS等）工作。

（4）课题组长唐开福简介

1972年3月出生，博士，温州医科大学基因组医学研究院研究员。兼任温州医科大学附属第一医院感染科教授、肝病研究所副主任。浙江省杰出青年基金获得者(2011年)；浙江省151人才工程第三层次培养人员(2011年)；浙江省151人才工程第二层次培养人员(2012年)；温州市551第一层次培养人员；《Frontiers in Gastrointestinal Cancers》编委；World Journal of Biological Chemistry编委；BIT'S 3rd Annual world DNA and Genome Day 顾问委员会成员；《中华肝脏病杂志》通讯编委；教育部创新团队成员。近5年以来主持国家自然科学基金4项、其他项目共7项；作为骨干参与艾滋病和病毒性肝炎等重大传染病防治专项1项；参加国家自然科学基金8项。获得各类人才项目共4项。获重庆市科技进步一等奖、教育部科技进步二等奖、中华医学科技奖二等奖等共6项。发表文章50余篇。

部分文章及专著（*为通讯作者，IF为近5年平均影响因子）

1 Wu J, Zhang XJ, Shi KQ, Chen YP, Ren YF, Song YJ, Li G, Xue YF, Fang YX, Deng ZJ, Xu X, Gao J, Tang KF*. Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells. Carcinogenesis. 35(1):155-63. 2014.  ( IF=5.557)

2 Tang KF*, Ren H, Cao J, Zeng GL, Xie J, Chen M, Wang L, He CX. Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB. J Cell Biol. 182(2):233-9. 2008. (IF=10.367)

3 Wu J, Wu g, Lv L, R YF, Zhang XJ, Xue YF, Li G, Lu XC, Sun ZS, Tang KF*. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis. 33(3):519-28. 2012. ( IF=5.557)

4 Ren YF, Li G, Xue YF, Zhang XJ, Song YJ, Lv L, Wu J, Fang YX, Wang YQ, Shi KQ, Chen YP, Tang KF*. Decreased dicer expression enhances SRP-mediated protein targeting. PLoS One. 8(2):e56950. 2013. (IF=4.244)

5 Ren YF, Li G, Wu J, Xue YF, Song YJ, LV L, Zhang XJ, Tang KF*. Dicer-Dependent Biogenesis of Small RNAs Derived from 7SL RNA. PLoS One. 7(7):e40705. 2012. (IF=4.244)

6 Tang KF, Song GB*, Shi YS, Yuan L, Li YH. Dicer knockdown induces fibronectin-1 expression in HEK293T cells via induction of Egr1. Biochim Biophys Acta. 1800(3):380-4.2010. ( IF=4.204)

7 Tang KF*, Wang Y, Wang P, Chen M, Chen Y, Hu HD, Hu P, Wang B, Yang W, Ren H*. Upregulation of PHLDA2 in Dicer knockdown HEK293 cells. Biochim Biophys Acta. 1770(5):820-5. 2007. ( IF=4.204)

8 Sun XR, Wu, Shi KQ, Tang KF*. Relationship between IL-10 gene -1082A/G and -592C/A polymorphisms and the risk of hepatitis C infection: a meta-analysis. J Viral Hepat. 20(9):602-11. 2013. ( IF=3.251)

9 Tang KF*, Chen M, Xie J, Song GB, Shi YS, Liu Q, Mei ZC, Steinle A, Ren H*. Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells. Med Microbiol Immunol. 198 (1): 27-32. 2009. ( IF=3.278)

10 Tang KF*, He CX, Zeng GL, Wu J, Song GB, Shi YS, Zhang WG, Huang AL, Steinle A, Ren H*. Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine. Biochem Biophys Res Commun. 370(4):578-83. 2008. ( IF=2.5)

11 Wu JF, Shen W, Liu NZ, Zeng GL, Yang M, Zuo GQ, Gan XN, Ren H, Tang KF*. Down-regulation of Dicer in hepatocellular carcinoma. Med Oncol. 28(3):804-9. 2011. (IF=1.96)

12 Tang KF*, Xie J, Chen M, Liu Q, Zhou XY, Zeng W, Huang AL, Zuo GQ, Wang Y, Xiang R, Ren H*. Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication. Biologicals. 36(3):177-83. 2008. (IF=1.538)

13 Shi KQ, Tang JZ, Zhu XL, Ying L, Li DW, Gao J, Fang YX, Li GL, Song YJ, Deng ZJ, Wu JM, Tang KF*. Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: A meta-analysis of diagnostic accuracy. J Gastroenterol Hepatol. 2014 Jan 29. doi: 10.1111/jgh.12519. [Epub ahead of print]. (IF=3.08)

14 Li G, Li DW, Fang YX, Song YJ, Deng ZJ, Gao J, Xie Y, Yin TS, Ying L*, Tang KF*. Performance of shear wave elastography for differentiation of benign and malignant solid breast masses. PLoS One. 8(10):e76322. 2013. (IF=4.244)

15 Shi KQ, Lin Z, Li DW, Fang YX, Gao J, Deng ZJ, Chen L, Li GL, Wu JM, Tang KF*. Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.  Onkologie. 36(10):560-5. 2013. (IF=1.031)

16 Ying L, Lin X, Xie ZL, Hu YP, Tang KF*, Shi KQ*.  Clinical utility of endoscopic ultrasound elastography for identification of malignant pancreatic masses: a meta-analysis. J Gastroenterol Hepatol. 28(9):1434-43. 2013. (IF=3.08)

17 Deng ZJ, Shi KQ, Song YJ, Fang YX, Wu J, Li G, Tang KF, Qu J*. Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies. Ophthalmologica. 2014 Feb 8. [Epub ahead of print]. (IF=1.236)

18 Tang KF*, Ren H*. The role of dicer in DNA damage repair. Int J Mol Sci. 13(12):16769-78.2012. (IF=2.732)

19 Hu P, Hu HD, Chen M, Peng ML, Tang L, Tang KF, Matsui M, Belladonna ML, Yoshimoto T, Zhang DZ, Xiang R, Ren H*. Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma. Mol Immunol. 46(8-9):1654-62. 2009. (IF=2.917)

20 Chen M, Zhang D, Zhen W, Shi Q, Liu Y, Ling N, Peng M, Tang K, Hu P, Hu H, Ren H*. Characteristics of circulating TCRγδT cells from individuals chronically infected with HBV: an association between Vδ2T subtype and chronic HBV infection. J Infect Dis. 198(11):1643-50. 2008. (IF= 5.914)

21 Sun XR, Wu J, Tang KF*. The interferon-gamma (IFN-y) +874T allele reduces
the risk of hepatitis B infection in an Asian population. J Viral Hepat, (In press) ( IF=3.251).

22 Hu P, Peng ML, Chen M, Hu HD, Tang L, Tang KF, Ren H*. （2009）Molecular cloning, expression and characterization of an interleukin 27 p28 homolog in pig (Sus scrofa).Vet Immunol Immunopathol. 130(3-4):262-7. IF=2.163.

23 Shi N, Zhou W, Tang K, Gao Y, Jin J, Gao F, Peng X, Bartlam M, Qiang B*, Yuan J*, Rao Z*. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2170-2. IF=7.54

24  Yu-Qun Wang 1,2#, Yong-Feng Ren 1#, Yi-Jiang Song 1#, Yong-Feng Xue 1, Xue-Jiao Zhang 1, Su-Ting Cao1,2, Zhu-Jun Deng 1, Guiling Li 1, Jianmin Wu 1, Ke-Qing Shi2, Yong-Ping Chen2, Kai-Fu Tang1 *. MicroRNA-581 Promotes Hepatitis B Virus Surface Antigen Expression by Targeting Dicer and EDEM1, Carcinogenesis (In revision). ( IF=5.557)

25 Yan Wang1,2, Lin Chen3, Guiling Li4, Lu lv4, Wei Dai1, Guan Wang5, Enfeng Zhao5, Kai-Fu Tang4*, Zhong Sheng Sun3,4*. Epigenetic Inactivation of Ras-related Associated with Diabetes (RRAD) Promotes Glucose Uptake in a Human Ovarian Cancer Model, J Biol Chem (In revision). IF=5.023.

26 Kai-Fu Tang*, Gui-Li Zeng, Jinfeng Wu and Hong Ren, Idenditifaction and characterization of Dicer-regulated noncoding RNAs, International Drug Discovery Science and Technology (IDDST),(pp 249) Beijing, 2008.10.18-22, Keynote speaker.

27 Kai-Fu Tang*, Histocompatibility (Dicer regulates the expression of major histocompatibility complex (MHC) class I chain-related genes A and B), InTech, (英文专著).

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