山东大学

主要是从植物激素尤其是生长素和细胞分裂素调控的角度，综合利用遗传学、细胞学和分子生物学、转录组学和蛋白组学等各种手段，研究植物根在铝，铬及营养缺陷等各种非生物逆境胁迫条件下根尖干细胞和根的可塑性生长发育的分子调控机制。近5年来，先后在Cell Reports, EMBO Reports, PLOS Genetics， Plant cell, Trends in Biotechnology , Trends in Plant Science, EMBO Journal, Nature Communications, Development, Plant Physiology, Plant Journal, Molecular Plant,等国际主流期刊发表近40篇学术论文。

本实验室常年招收博士后研究人员，欢迎加入！

联系邮箱：dingzhaojun@sdu.edu.cn

4、主持项目：

1）国家基础研究973重大研究（2015-2019），480万，主持

2）国家基金委“优秀青年科学基金”（2013-2015），100万，主持

3）国家基金委面上项目（2013-2014），90万，主持

4）国家基金委面上项目（2015-2018），90万，主持

5）国家基金委面上项目（2017-2020），75万，主持

6）国家基金委面上项目（2019-2022），75万，主持

7）山东省“杰出青年科学基金”（2015-2017），60万，主持

8）植物干细胞诱导及应用（2017-2019）,115万，主持

5、近几年来发表的主要研究论文(*通讯)：

1）Lv B＃, Yan Z＃, Tian H*, Zhang X*, Ding Z*. Local Auxin Biosynthesis Mediates Plant Growth and Development. Trends Plant Sci. 2018, (18):30247-4.

2）Yang S, Yu Q, Zhang Y, Jia Y, Wan S*, Kong X*, Ding Z*. ROS: The Fine-Tuner of Plant Stem Cell Fate. Trends Plant Sci. 2018 23(10):850-853.

3）Kong X#*, Li C#, Zhang F, Yu Q, Gao S, Zhang M, Tian H, Zhang J, Yuan X, Ding Z. *, Ethylene promotes cadmium-induced root growth inhibition through EIN3 controlled XTH33 and LSU1 expression in Arabidopsis. Plant Cell and Environment. 2018, 41(10):2449-2462.

4）Zhang M, Lu X, Li CL, Zhang B, Zhang C, Zhang XS, Ding Z*. Auxin Efflux Carrier ZmPGP1 Mediates Root Growth Inhibition under Aluminum Stress. Plant Physiol. 2018 Jun;177(2):819-832.

5）Tian Y, Fan M, Qin Z, Lv H, Wang M, Zhang Z, Zhou W, Zhao N, Li X, Han C, Ding Z, Wang W, Wang ZY, Bai MY. Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor. Nat Commun. 2018 Mar 14;9(1):1063.

6）Kong X#, Liu G. #, Liu J. and Ding Z*. The Root Transition Zone: A Hot Spot for Signal Crosstalk. Trends Plant Sci. 2018, May;23(5):403-409.

7）Tian H#*, Lv B#, Ding T, Bai M*, Ding Z*. Auxin-BR Interaction Regulates Plant Growth and Development. Front Plant Sci., 2018, 18;8:2256-

8）Kong X, Tian H, Yu Q, Zhang F, Wang R, Gao S, Xu W, Liu J, Shani E, Fu C, Zhou G, Zhang L, Zhang X. and Ding Z*. PHB3 maintains root stem cell niche identity through ROS responsive AP2/ERF transcription factors in Arabidopsis. Cell Reports, 2018, 22(5):1350-1363.

9）Lv B, Tian H, Zhang F, Liu J, Lu S, Bai M, Li C. and Ding Z*. Brassinosteroids regulate root growth by controlling reactive oxygen species homeostasis and dual effect on ethylene synthesis in Arabidopsis PLOS Genetics, 2018, 14(1):e1007144..

10）Yang ZB#, Liu G#, Liu J, Zhang B, Meng W, Müller B, Hayashi KI, Zhang X, Zhao Z, De Smet I, Ding Z*. Synergistic action of auxin and cytokinin mediates aluminum-induced root growth inhibition inArabidopsis. EMBO Rep. 2017, 18(7):1213-1230.

11）Geng X, Horst WJ, Golz JF, Lee JE, Ding Z*, Yang ZB*. LEUNIG_HOMOLOG Transcriptional Co-repressor Mediates Aluminum Sensitivity through PECTIN METHYLESTERASE46-Modulated Root Cell Wall Pectin Methylesterification in Arabidopsis. Plant J. 2017 May;90(3):491-504.

12）Shin J, Sánchez-Villarrl A, Davis AM, Du SX, Berendzen KW, Koncz C, Ding Z, Li C, Davis SJ. The metabolic sensor AKIN10 modulates the Arabidopsis circadian clock in a light-dependent manner。Plant Cell Environ. 2017, 40(7):997-1008.

13）Yang Z#, He C#, Ma Y, Herde M, Ding Z*. Jasmonic acid enhances Al-induced root-growth inhibition. Plant Physiol. 2017 Feb;173(2):1420-1433.

14）Kong X. Tian H and Ding Z. Plant Hormone Signaling Mediates Plant Growth Plasticity in Response to Metal Stress. Mechanism of Plant Hormone Signaling under Stress, 2017, Volume 2: 223-235.

15）Sun Y, Mu C, Chen Y, Kong X, Xu Y, Zheng H, Zhang H, Wang Q, Xue Y, Li Z, Ding Z, Liu X*. Comparative transcript profiling of maize inbreds in response to long-term phosphorus deficiency stress. Plant Physiol Biochem. 2016, 109:467-481.

16）Liu G, Gao S, Tian H, WuW, Robert H and Ding Z*. Local transcriptional control of YUCCA regulates auxin promoted root-growth inhibition in response to aluminium stress in Arabidopsis. PLOS Genetics, 2016, 12(10):e1006360. doi: 10.1371/journal.pgen.1006360..

17）Yu Q, Tian H，Yue K and Ding Z*. A P-loop NTPase regulates quiescent center cell division and distal stem cell identity through the regulation of ROS homeostasis in Arabidopsis root. PLOS Genetics, 2016, 1;12(9):e1006175.

18）Kong X, Zhang L, Ding Z*. 26S Proteasome: Hunter and Prey in Auxin Signaling. Trends Plant Sci. 2016 Jul;21(7):546-8.

19）Yu Q, Liu J, Zheng H, Jia Y, Tian H*, Ding Z. Topoisomerase II-associated protein PAT1H1 is involved in the root stem cell niche maintenance in Arabidopsis thaliana. Plant Cell Rep. 2016, 35(6):1297-307.

20）Jiao Y#, Hamant O#, Ding Z#, Zhang XS*. Meristem Biology Flourishes Under Mt. Tai. Mol Plant. 2016, 9(8):1224-1227.

21）Kong X, Lu S, Tian H. and Ding Z*. WOX5 is shining in the root stem cell niche. Trends Plant Sci. 2015, Oct;20(10):601-3.

22）Jia Y, Tian H, Li H, Yu Q, Wang L, Friml J, Ding Z*. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. J Exp Bot. 2015 Aug;66(15):4631-42.

23）Sun Y, Kong X, Li C, Liu Y, Ding Z*. Potassium Retention under Salt Stress Is Associated with Natural Variation in Salinity Tolerance among Arabidopsis Accessions. PLoS One. 2015 May 19;10(5):e0124032

24）Fan L, Li R, Pan J, Ding Z, Lin J. Endocytosis and its regulation in plants. Trends Plant Sci. 2015 (15)00081-3.

25）Zhang M, Kong X, Xu X, Li C, Tian H, Ding Z*. Comparative transcriptome profiling of the maize primary, crown and seminal root in response to salinity stress. PLoS One. 2015 Mar 24;10(3):e0121222.

26）Kong X, Zhang M, De Smet I and Ding Z*. Designer crops: optimal root system architecture for nutrient acquisition. Trends in Biotechnology. 2014, Dec;32(12):597-8.

27）Yang Z, Geng X, He C, Wang R, Zhang F, Horst W and Ding Z*. TAA1-regulated local auxin biosynthesis in the root-apex transition-zone mediates the aluminum-induced inhibition of root growth in Arabidopsis, Plant Cell. 2014, Jul;26(7):2889-904.

28）Kong X, Zhang M , Xu X, Li X, Li C and Ding Z*. System analysis of MicroRNAs in the development and aluminium-stress responses of the maize root system. , Plant Biotechnol J. 2014，Oct;12(8):1108-21.

29）Kong X, Zhang M, Ding Z*. D53: the missing link in strigolactone signaling. Mol Plant. 2014 May;7(5):761-3.

30）Tian H, De Smet I* and Ding Z*. Shaping a root system: regulating lateral versus primary root growth. Trends Plant Sci. 2014 Jul;19(7):426-31.

31）Tian H, Jia Y, Niu T, Yu Q and Ding Z*. The key players of the primary root growth and development also function in lateral roots in Arabidopsis. Plant Cell Rep. 2014, 33(5):745-753.

32）Le J, Liu XG, Yang KZ, Chen XL, Zou JJ, Wang HZ, Wang M, Vanneste S, Morita M, Tasaka M, Ding Z, Friml J, Beeckman T, Sack F. Auxin transport and activity regulate stomatal patterning and development. Nature Communications. 2014 Jan 27;5:3090.

33）Tian H, Wabnik K, Niu T, Li H, Yu Q, Pollmann S, Vanneste S, Govaerts W, Rolcík J, Geisler M, Friml J, Ding Z*. WOX5-IAA17 feedback circuit mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis. Mol Plant. 2014 Feb;7(2):277-289.

34）Tian H, Niu T, Yu Q, and Ding Z*. Auxin gradient is crucial for the maintenance of root distal stem cell identity in Arabidopsis. Plant Signaling & Behavior, 2013, Sep 20;8(12). pii: e26429.

35Ding Z* and De Smet I*. Localised ABA signalling mediates root growth plasticity. Trends Plant Sci. 2013 Oct;18(10):533-535.

36）Alfredo SV, Jieun S, Nora B, Toshihiro O, Ulla N, Du SX, Ding Z, Davis A, Shindo T, Schmelzer E, Sulpice R, Nesi A, Stitt M, Fernie A, Davis S. TIME FOR COFFEE is an Essential Component in the Maintenance of Arabidopsis thaliana Metabolic Homeostasis. The Plant Journal. 2013 Oct;76(2):188-200.

37）Fan LS, Hao HQ, Xue YQ, Zhang L, Song K, Ding Z, Botella MA, Wang HY, Lin JX. Dynamic analysis of Arabidopsis AP2 σ reveals its key role in clathrin-mediated endocytosis and plant development, Development, 2013，140(18):3826-37.

38）Marhavý P, Vanstraelen M, De Rybel B, Ding Z, Bennett MJ, Beeckman T, Benková E. Auxin reflux between the endodermis and pericycle promotes lateral root initiation. EMBO J. 2013 Jan 9;32(1):149-58.

39）Ding Z, Wang B, Moreno I, Dupláková N, Simon S, Carraro N, Reemmer J, Pěnčík A, Chen X, Tejos R, Skůpa P, Pollmann S, Mravec J, Petrášek J, Zažímalová E, Honys D, Rolčík J, Murphy A, Orellana A, Geisler M, Friml J. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Nature Communications. 2012 Jul 3;3:941-947.

40）Ding Z, Carlos S. Galván Ampudia, Emilie Demarsy, Lukasz .angowski, Jürgen Kleine-Vehn,Yuanwei Fan, Miyo T. Morita, Masao Tasaka, Christian Fankhauser, Remko Offringa and Jirí Friml. Light-mediated polarization of auxin transport for phototropic response in Arabidopsis. Nat Cell Biology. 2011 Apr;13(4):447-52.

41）Kleine-Vehn J, Ding Z, Angharad R. Jones, Masao Tasaka, Miyo T. Gravity-induced PIN transcytosis for polarization of auxin fluxes in gravity-sensing root cells. PNAS, 2010, 107(51):22344-9.

42）Ding Z and Friml J. Auxin regulates distal stem cell differentiation in Arabidopsis roots. PNAS, 2010,107(26):12046-51.

43）Zádníková P, Petrásek J, Marhavy P, Raz V, Vandenbussche F, Ding Z, Schwarzerová K, Morita MT, Tasaka M, Hejátko J, Van Der Straeten D, Friml J, Benková E.　Role of PIN-mediated auxin efflux in apical hook development of Arabidopsis thaliana.Development, 2010, 137(4):607-17.

44）Ding Z, Millar AJ, Davis AM, Davis SJ. TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thalianacircadian clock.　Plant Cell, 2007, 19(5):1522-36.

45）Ding Z, Doyle MR, Amasino RM, Davis SJ. A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation.Genetics, 2007, 176(3):1501-10.(Issue highlighted paper).

46）Ding Z, Deng Z, Tao J, Zhang L and Wang T. The molecular mechanism of chromosome segregation. Chinese Science Bulletin, 2003, 47(4)2014-2021.

47）Wang T, Ding Z. The Research Development of Genes about Meiosis. Chinese Science Bulletin, 2002, 47(4)241-248.

48）Ding Z, Wu X and Wang T. The Rice Tapetum-specific Gene RA39 Encodes a TypeI Ribosome-inactivating Protein. Sex Plant Reprod, 2002, 15:205-212.

49）Ding Z, Wang T, Chong K and Bai S. Isolation and Characterization of OsDMC1, the Rice Homologue of the Yeast DMC1 Gene Essential for Meiosis. Sex Plant Reprod, 2001,13: 285-288.